Andy Shedlock

Andrew Shedlock

Associate Professor


Ph.D. - University of Washington
M.S. - University of Washington
B.S. - Cornell University

Research Interests

The Shedlock Lab integrates genome annotation, transcriptomics, and population scale genome-wide variation to understand the evolutionary mechanisms driving biological complexity and diversity in nature, with a taxonomic emphasis on marine vertebrates. Through this global comparative hypothesis-driven program of experimental and computational investigation we seek to advance more predictive vs reactive approaches to complex problem solving in the environmental sciences and public policy.


Graduate Program in Marine BiologyGraduate Program in Environmental StudiesMUSC College of Graduate Studies

Courses Taught

BIOL 101: Concepts and Applications in Biology
FYER 111: Freshman Research Rotation
BIOL 111: Introduction to Cell and Molecular Biology
BIOL 312+312L: Molecular Biology Lecture and Lab
BIOL 412: Capstone in Molecular Biology
BIOL 427+527: Marine Tetrapod Biology
DATA 495: Data Science Capstone
BIOL 649+649L: Comparative Genomics Lecture and Lab
BIOL 650: Conservation Genetics and Genomics
EVSS 671+671L: Biodiversity Management Lecture and Lab

Selected Publications

Chow J. C., P. A. Anderson, and A. M. Shedlock.  2019. Sea turtle population genomic discovery: Global and locus-specific signatures of polymorphism, selection, and adaptive potential. Genome Biology and Evolution 11(10):2797-2806. DOI: 10.1093/gbe/evz190. [cover article]

Adema C. M., L. W. Hillier, C. S. Jones, E. S Loker, M. Knight, P. Minx, G. Oliveira, N. Raghavan, A. M. Shedlock, et al. 2017. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications 8:15451, DOI: 10.1038/ncomms15451, May 2017.

Shaffer, H. B., P. Minx, D. E. Warren, A. M. Shedlock, R. C. Thomson, N. Valenzuela, J. Abrahamian, C. T. Amemiya, et al. 2013. The Western Painted Turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biology 14:R28 doi:10.1186/gb-2013-14-3-r28. [cover article]

Alfoldi, J., F. DiPalma, M. Grabherr, C. Williams, L. Kong, E. Mauceli, P. Russell., C. Lowe, R. Glor, J. D. Jaffe, D. Ray,  A. M. Shedlock, et al.  2011.  The green anole lizard genome: the first reptilian genome and a comparative analysis with birds and mammals.  Nature 477:587-591.

Shedlock, A. M., C. W. Botka, S. Zhao, J. Shetty,T. Zhang, J. S. Liu, P. J. Deschavanne, and S. V. Edwards. 2007. Phylogenomics of non-avian reptiles and the structure of the ancestral amniote genome. Proc. Natl. Acad. Sci. USA. 104:2767-2772.

Organ, C. L., A. M. Shedlock, A. Meade, M. Pagel, and S. V. Edwards2007. Origin of avian genome size and structure in nonavian dinosaurs.  Nature 446:180-184.

Shedlock, A. M. 2006. Phylogenomic investigation of CR1 LINE diversity in reptiles.  Systematic Biology 55(6):902-911. [cover article]

Wasser, S. K., A. M. Shedlock, , K. E. Comstock, E. O. Ostrander, B. Mutayoba and M. Stephens. 2004. Assigning African elephant ivory to a geographic region of origin: Applications to the ivory trade. Proc. Natl. Acad. Sci. USA 101(41): 14847-14852 [cover article ].

Nikaido, M., F. Matsuno, H. Hamilton, R. L. Brownell Jr., W. Ding, Z. Zuoyan, Y. Cao, A. M. Shedlock, E. Fordyce, M. Hasegawa, and N. Okada.  2001.  Retroposon analysis of major cetacean lineages:  The monophyly of toothed whales and the paraphyly of river dolphins.  Proc. Natl. Acad. Sci. USA. 98:7384-7389.

Shedlock, A. M., M. C. Milinkovitch, and N. Okada.  2000.  SINE evolution, missing data, and the origin of whales.  Systematic Biology 49(4):808-817. [cover article].