M Janech

Michael Janech


Associate Professor, SC SmartStateĀ® Endowed Chair in Marine and Environmental Health

Education

Ph.D. – Medical University of South Carolina
M.S. – University of Charleston
B.S. – Oakland University

Research Interests

Research in my laboratory focuses on mass spectrometry as an analytical tool to study comparative mechanisms underlying physiology and pathophysiology at the level of proteins.  These studies are complemented by the use of proteomics, which is the study of many proteins at one time and their post-translational modifications.  Interests include:  

1) comparative proteomics and metaproteomics,

2) biomarkers of human and marine mammal disease,

3) mechanisms of osmoregulation and kidney function,

My laboratory is funded by an NIH/NIDDK R15 to oversee the UROCUP program: Undergraduate Research Opportunity to explore the Composition of Urinary casts using Proteomics. UROCUP is a collaboration between CofC, Ochsner Medical Center – Nephrology, NIST, and University of Arkansas for Medical Sciences. Undergraduates utilize proteomics to discover proteins associated with urinary casts which assist in diagnosing and understanding mechanisms of acute kidney injury.

My laboratory is a lead participant in the NIST COMPARE project, which is a multi-institutional effort to characterize proteome differences between mammals to identify proteins that correlate with unique physiological adaptations.

Affiliations

Adjunct Faculty, Medical University of South Carolina, Department of Medicine
Science Board Member, Hollings Marine Laboratory, Charleston, SC

Courses Taught

BIOL 111:  Introduction to Cell and Molecular Biology
BIOL 399/499/690: Independent Study

Selected Publications

Hoard, V. F.; Janech, M. G., Neurological deficits in stranded California sea lions. The Veterinary record 2019, 185, (10), 301-303.

Hopkins, J.; Velez, J. C. Q.; Arthur, J. M.; Janech, M. G., Are Undergraduates Familiar with Nephrology as a Medical Specialty? A Single Site Survey of Undergraduate Students. Kidney360 2022, 3, (8), 1332-1340.

Neely, B. A.; Janech, M. G.; Fenton, M. B.; Simmons, N. B.; Bland, A. M.; Becker, D. J., Surveying the Vampire Bat (Desmodus rotundus) Serum Proteome: A Resource for Identifying Immunological Proteins and Detecting Pathogens. Journal of proteome research 2021, 20, (5), 2547-2559.

Neely, B. A.; Prager, K. C.; Bland, A. M.; Fontaine, C.; Gulland, F. M.; Janech, M. G., Proteomic Analysis of Urine from California Sea Lions ( Zalophus californianus): A Resource for Urinary Biomarker Discovery. Journal of proteome research 2018, 17, (9), 3281-3291.

Saito, M. A.; Bertrand, E. M.; Duffy, M. E.; Gaylord, D. A.; Held, N. A.; Hervey, W. J. t.; Hettich, R. L.; Jagtap, P. D.; Janech, M. G.; Kinkade, D. B.; Leary, D. H.; McIlvin, M. R.; Moore, E. K.; Morris, R. M.; Neely, B. A.; Nunn, B. L.; Saunders, J. K.; Shepherd, A. I.; Symmonds, N. I.; Walsh, D. A., Progress and Challenges in Ocean Metaproteomics and Proposed Best Practices for Data Sharing. Journal of proteome research 2019, 18, (4), 1461-1476.

Sobolesky, P.; Parry, C.; Boxall, B.; Wells, R.; Venn-Watson, S.; Janech, M. G., Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype. Scientific reports 2016, 6, 33879.

Sobolesky, P. M.; Harrell, T. S.; Parry, C.; Venn-Watson, S.; Janech, M. G., Feeding a Modified Fish Diet to Bottlenose Dolphins Leads to an Increase in Serum Adiponectin and Sphingolipids. Frontiers in endocrinology 2016, 7, 33.

Velez, J. C. Q.; Arif, E.; Rodgers, J.; Hicks, M. P.; Arthur, J. M.; Nihalani, D.; Bruner, E. T.; Budisavljevic, M. N.; Atkinson, C.; Fitzgibbon, W. R.; Janech, M. G., Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury. Journal of the American Society of Nephrology : JASN 2017, 28, (7), 2119-2132.