Renaud Geslain

Renaud Geslain

Associate Professor

Education

Ph.D. - The University of Strasbourg, France
B.S. - The University of Strasbourg, France

Research Interests

I am a Molecular and Cellular Biologist. My research interest focuses on the study of RNA-protein interactions: from their discovery and characterization to their therapeutic applications. My area of study is the translational machinery used by every living organism to produce proteins from messenger RNA. Proteins are essential because they shape the cell, perform biochemical reactions and support intra- and intercellular communication. My laboratory combines approaches such as molecular biology, cell culture, RNA microarray, genetics and drug design.

Affiliations

Honors Advising Fellow
CAPP Faculty Fellow

Courses Taught

BIOL 111: Introduction to Cell and Molecular Biology
BIOL 312: Molecular Biology
CHEM 483: Nucleic Acids in Research, Biotechnology, and Medicine

Selected Publications

Cela M., Théobald-Dietrich A., Rudinger-Thirion J., Wolff P., Geslain R. and Frugier M. (2021). Identification of host tRNAs preferentially recognized by the Plasmodium surface protein tRip. Nucleic Acids Research. 49(18):10618-10629 - PMID: 34530443

Pernod K., Schaeffer L., Chicher J., Hok E., Rick C., Geslain R., Eriani G., Westhof E., Ryckelynck M. and Martin F. (2020). The nature of the purine at position 34 in tRNAs of 4-codon boxes is correlated with nucleotides at positions 32 and 38 to maintain decoding fidelity. Nucleic Acids Research. 48(11):6170-6183 - PMID: 32266934.

Grelet S., Geslain R., Howe P.H. (2018). EMT does not work regular shifts. Cell Cycle 15:1-2 - PMID: 29334820

Emetu S., Troiano M., Goldmintz J., Tomberlin J., Grelet S., Howe P.H., Korey C. and Geslain R. (2018). Metabolic labeling and profiling of transfer RNAs using macroarrays. Journal of Visualized Experiments 16(131) - PMID: 29364226

Grelet S., McShane A., Geslain R., Howe P.H. (2017). Pleiotropic Roles of Non-Coding RNAs in TGF-β-Mediated Epithelial-Mesenchymal Transition and Their Functions in Tumor Progression. Cancers 9(7). pii: E75 - PMID: 28671581

Grelet S., McShane A., Hok E., Tomberlin J., Howe H.P. and Geslain R. (2017). SPOt: a novel and streamlined microarray platform for observing cellular tRNA levels. PLoS ONE 12(5):e0177939 - PMID: 28545122.